Adenosine And Asthma
The text discusses the role of adenosine in causing bronchoconstriction and asthma in humans. It mentions that adenosine is formed from ADP and AMP by certain enzymes and has been shown to cause dyspnea in both normal and asthmatic individuals when administered intravenously. Several studies have found that inhaled adenosine is a potent bronchoconstrictor in asthmatic patients but not in normal individuals. This effect is thought to be mediated by mast cell activation and the release of histamine. Adenosine has also been linked to inflammatory airway diseases such as asthma and COPD. Overall, adenosine and its related nucleotide AMP are known to induce bronchoconstriction in asthmatics through various mechanisms, although further research is needed to fully understand the exact mechanism of action.
Adenosine plays a significant role in causing bronchoconstriction and asthma in humans. It is formed from ADP and AMP by certain enzymes and has been demonstrated to induce dyspnea in both normal and asthmatic individuals when administered intravenously. Inhaled adenosine is a potent bronchoconstrictor in asthmatic patients, believed to be mediated by mast cell activation and the release of histamine. Furthermore, adenosine has been associated with inflammatory airway diseases like asthma and COPD. It is known to induce bronchoconstriction in asthmatics through various mechanisms, with further research needed to fully understand the exact mechanism of action.
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